Numerous studies have found that 40-60% of embryos obtained through artificial methods such as test-tube baby technology have chromosomal abnormalities. These chromosomal abnormalities are the main cause of pregnancy failure and spontaneous abortion. As pregnancy age advances, embryos become aneuploidy, and live birth rate decreased significantly. Biopsy showed a high rate of chromosomal aneuploidy in both D3 and D5 stages. PGT-A can directly detect the chromosomes of embryos, which is beneficial to screen out embryos with normal chromosomes for transplantation. Through PGT-A, it can significantly increase the implantation success rate and pregnancy rate, while reducing the miscarriage rate and physical and psychological negative effects of miscarriage for women.

Yikon Genomics provides specific sample collection tubes. Each collection tube contains 5ul sample storage solution. Put the biopsy cells (no more than 2ul PBS) in the collection tube and store it below -20°C. Contact local sales staff as soon as possible. Shipped with dry ice.

1. The biopsy cells contain both normal and abnormal cells, or cell debris is found in the biopsy.
2. The biopsy cells are contaminated by external sources, such as granular cells, unfertilized sperm, etc.
3. The cell is in the division phase and the chromosome replication is not synchronized.

In the absence of completely normal embryos, you can consider transferring chimeric embryos, but you need to consider the type and proportion of chimerism. For transplantation standards, please refer to "An evidence-based scoring system for prioritizing mosaic aneuploid embryos following preimplantation genetic screening[J]. Reproductive BioMedicine Online, 2018:S1472648318300385."

PGTA-ChromInst^® molecular genetic testing can only detect the deletion or duplication of embryos above 4Mb, and cannot detect structural abnormalities. If you need to distinguish the structural abnormalities of the embryos, you can use the MaReCs^® chromosomal translocation carrying test of Yikon Genomic, which can distinguish between balanced translocations carryingembyos and normal embryos.