Recurrent Implantation Failure

According to statistics, the number of IVF cycles per year in our country in 2018 is more than 1 million. However, the rate of recurrent implantation failure was as high as 11.1%. Embryo implantation is a complex process requiring synchronized endometrial receptivity and blastocyst competence. Therefore, in order to increase the pregnancy rate of assisted reproduction, it is necessary to screen a relatively viable embryo, and on the other hand, to ensure that the embryo is transferred during the endometrial receptivity period. Studies have shown that nearly 1/4-1/3 of the population will experience shift or shortening of the window of endometrial implantation (WOI), resulting in failure to pregnancy or recurrent embryo transfer failure. Therefore, by detecting endometrial receptivity and predicting the window of implantation (WOI), it can guide the individualized embryo transfer, improve the outcome of in vitro fertilization and embryo transfer (IVF-ET).

Clinical Pathway

Case Studies

Patient with 4 implantation failure during 2 cycles

MR. and Ms. Wang have not successfully given birth to a child since their marriage before 2 years. She was confused because she had always stable menstruation and had no dysmenorrhea or other diseases. She didn't think much about it. Being pressed by long-term infertility and her families, she went to the hospital for an examination in 2011 at the local Maternal and Child Health Hospital. The examination result of MR. Wang was completely normal, however the tubal radiography of Mrs. Wang showed secondary infertility, left fallopian tube obstruction, and right fallopian tube incomplete obstruction. They decided to do IVF.
In March of 2011, Mrs. Wang came to a hospital in Beijing to do test tubes. She underwent a total of 4 transplant within two cycles, but all failed. In the first cycle, the doctor formulated an ultra-long plan, fetching 15 eggs, fertilizing 5 eggs, and transplanting 2 eggs, which ended in failure. In June and August of 2011, two frozen embryo transfers were done, which also failed. After two months of recuperation, she entered the second cycle.
This time it was changed to a short plan, with 20 eggs retrieved, 6 fertilized, and 1 transplanted, but it failed.

After several consecutive failures, the doctor advised them to do chromosome test and embryo genetic test. The results of the test showed that the chromosomes and other indi were normal. However, PGT-A test showed that only two of six embryos had normal chromosomes and the remaining four contained chromosomal abnormalities such as triploid chromosome 21, tetraploid chromosome 16, mosaic, and etc. Finally, one of the healthy embryos with normal chromosomes was selected for transplantation. Holding not much hope, this couple was surprised that 10 days after the transplantation. the hcg test showed a successful pregnancy. At that time, Mrs. Wang and her family were very excited. During the pregnancy period, she tried to be happy every day. The intake of fish, egg, milk and milk was also supplemented strictly in accordance with the doctor’s recommendations. Although there were slight ups and downs throughout the pregnancy, it was passed smoothly. A healthy baby was born in early 2012.