After the permission policy of second-child, there are about 90 million couples meeting the standards in China, of which 60 million women are over 35 years old. However, the fertility level of women over 35 years old begins to decline significantly with age. At 35-39 years old, it drops by 25% than before, and at 40-45 years old drops by 95%. According to the 2014 opinion of the American Society of Obstetrics and Gynecology, women older than 35 years old, who haven’t been pregnant for half a year, must start infertility related tests and treatments; women older than 40 years old can start infertility related tests and treatments at any time. According to actual conditions such as the pregnancy rate, live birth rate, miscarriage rate, and deformity rate of the elderly, IVF assisted reproductive technology is the most effective among all infertility treatment methods. It can help most elderly women achieve true eugenics !
I am 37 years old and from Hubei. As my career is relatively stable, I plan to have a second child. However, I failed after 6 months. So we went to the reproductive center of the hospital for infertility related tests: hormones, transvaginal ultrasonography and semen test.
The results showed that the AMH value was 0.8 ng/ml. At the doctor recommendation, I got an inducing ovulation treatment to get pregnant naturally. One month later, the menstruation came and the pregnancy plan failed.
Considering my elder age preparing and my twice pregnancy failure, the doctor suggested IVF to me. After examination and conditioning, only 10 eggs were obtained l, and 4 were successfully raised. After evaluating the morphology of the blastocyst stage, one embryo was graded 4BB. Unfortunately, the first transplant also ended in failure.
My husband and I did not give up and entered the second cycle. A total of 8 eggs were collected in this cycle and 3 were successfully raised. There was only one embryo with a better morphological assessment (4BA), and the rest were all 4BC grade. Therefore, fresh embryo transplantation was arranged on the fifth day. Given that the quantity and the quality of embryo is not ideal, the remaining 3 embryos with lower grades were frozen. Due to the failure of the first embryo transfer, the doctor suggested that the culture medium of the remaining 3 embryos should be sent for examination at the same time, to see if the embryos with low embryo ratings are unqualified as judged by morphology.
In the end, the second transplant failed. Just when I was considering whether to give up, the hospital's phone number gave new hope. It turned out that the report of the embryo culture medium they had sent before came out. The doctor said that embryos with high morphological evaluations may also have embryo chromosomal abnormalities, and the reverse is true. Therefore, in the second cycle of transplantation, it is recommended to send the culture medium of low-grade embryos. The culture fluid detection technology, also known as "NICS Non-invasive Embryo Implantation Priority Screening" can detect all chromosome aneuploidy of embryos, so that embryos without chromosomal abnormalities can be selected.
My husband and I both felt very lucky. The results of the "NICS Non-invasive Embryo Implantation Priority Screening" showed that of the 3 low-grade embryos, 1 was transferable. This is a huge surprise for us. So in full expectation, I transferred my only embryo again and got pregnant successfully. Now that my child has learned to walk, we are very grateful to this doctor. Had he not been so wise, I don't know how long it would take this day.
Optimization for the embryo selection and implantation priority
Comprehensively identify embryo chromosome aneuploidy to improve the success rate of IVF